CLINDAMYCIN-M

General Information

CLINDAMYCIN-M is an antibiotic from the lincosamide group with a broad spectrum of activity and bacteriostatic properties. It is active against many pathogens that cause infectious diseases, including Streptococcus pneumoniae, a common cause of pneumonia.

Due to its high efficacy, CLINDAMYCIN may be used for the treatment of a wide range of infectious and inflammatory diseases caused by microorganisms sensitive to clindamycin.

Following oral administration, clindamycin hydrochloride is rapidly and well absorbed from the gastrointestinal tract (better than lincomycin), with a bioavailability of approximately 90%. Concurrent food intake slows absorption but does not affect the extent of absorption.

Protein binding is 92–94%.

CLINDAMYCIN readily penetrates biological fluids, organs, and tissues of the body, including the tonsils (approximately 40% of the blood concentration), bronchi, lungs, pleura, pleural fluid (50–90%), saliva, and sputum (30–75%).

Composition

1 capsule contains clindamycin hydrochloride equivalent to 0.15 g (150 mg) of clindamycin.

Excipients: calcium stearate, lactose, colloidal silicon dioxide, sodium methylparaben, sodium propylparaben, gelatin, titanium dioxide, tartrazine, erythrosine, brilliant blue, and amaranth.

Indications

• Acute and chronic infections of the female reproductive system
• Lower respiratory tract infections (pneumonia, including aspiration pneumonia, bronchitis, lung abscess, pleural empyema)
• Upper respiratory tract and ENT infections (tonsillitis, pharyngitis, sinusitis, otitis)

Directions for Use

CLINDAMYCIN-M should be taken with an adequate amount of liquid (at least one full glass of water) to avoid possible irritation of the esophagus.

In cases of suspected infection caused by β-hemolytic streptococci, or when β-hemolytic streptococci are confirmed, treatment should continue for at least 10 days.

Adults

Depending on the location and severity of the infection, adults and children over 14 years of age should take 4–12 capsules per day (equivalent to 0.6–1.8 g of clindamycin).

The daily dose should be divided into 4 administrations.