PRIMANEIRA

GENERAL INFORMATION

Nervonic acid is a monounsaturated omega-9 fatty acid that supports the formation of the myelin sheath, brain development, and enhancement of cognitive functions [1]. It plays a key role in the synthesis of sphingolipids (gangliosides, cerebrosides, sphingomyelin), ensuring membrane stability and efficient transmission of nerve signals [2].

Acetyl-L-carnitine supports the metabolism of fats and carbohydrates, protects the brain from ischemia, and exhibits antioxidant and neuroprotective properties [3,4]. It promotes nerve regeneration by enhancing phospholipid synthesis for membranes and modulating nerve growth factors [5,6].

The active components of Primaneira stimulate the body’s natural repair processes and improve the condition of the central and autonomic nervous systems in the following conditions:

1. Peripheral nerve damage (compression, injuries);
2. Metabolic nerve fiber damage (e.g., diabetes);
3. Nerve fiber damage due to trauma (sprains, fractures, dislocations, swelling);
4. Post-infectious and toxic damage to nervous tissue.

COMPOSITION

Ingredients: Acetyl-L-carnitine – 250 mg, Nervonic acid (Acer truncatum Bunge extract) – 100 mg.
Excipients: Microcrystalline cellulose, calcium stearate, anti-caking agent: silicon dioxide.
Capsule shell: Gelatin.

Primaneira is recommended as a supplementary source of biologically active substances, such as acetyl-L-carnitine and nervonic acid. It supports the normal functioning of the nervous system, protects cells from free radical damage due to its antioxidant properties, and promotes healthy lipid and carbohydrate metabolism.

DIRECTIONS FOR USE

Recommended daily dose: 1 capsule 1–2 times per day, with or without food, taken with a sufficient amount of water. The dose may be adjusted based on age and individual needs after consulting a healthcare professional.
Do not exceed the recommended daily dose.
It is recommended to use for at least 1 month.
The course may be repeated 2–3 times per year as needed.

Literature Sources:

1. Liu, F., Wang, P., Xiong, X., Zeng, X., Zhang, X., & Wu, G. (2021). A Review of Nervonic Acid Production in Plants: Prospects for the Genetic Engineering of High Nervonic Acid Cultivars Plants. Frontiers in plant science, 12, 626625. https://doi.org/10.3389/fpls.2021.626625
2. Li, Q., Chen, J., Yu, X., & Gao, J. M. (2019). A mini review of nervonic acid: Source, production, and biological functions. Food chem­istry, 301, 125286. https://doi.org/10.1016/j.foodchem.2019.125286
3. Aureli, T., Di Cocco, M. E., Puccetti, C., Ricciolini, R., Scalibastri, M., Miccheli, A., Manetti, C., & Conti, F. (1998). Acetyl-L-carni­tine modulates glucose metabolism and stimulates glycogen synthesis in rat brain. Brain research, 796(1–2), 75–81. https://doi.org/10.1016/s0006–8993(98)00319–9
4. Ferreira, G. C., & McKenna, M. C. (2017). L–Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochemical research, 42(6), 1661–1675. https://doi.org/10.1007/s11064–017–2288–7
5. Passeri, M., Cucinotta, D., Bonati, P. A., Iannuccelli, M., Parnetti, L., & Senin, U. (1990). Acetyl-L-carnitine in the treatment of mildly demented elderly patients. International journal of clinical pharmacology research, 10(1–2), 75–79.
6. Magesh S. B, Rajappa R, Ramkumar K. M, Suryanarayanan S, Madhunapantula S. V. Acetyl-L–Carnitine Restores Abnormal Lipid Metabolism Induced by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin in Mice. Biomed Pharmacol J 2017;10(2).